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Amylin - Physiology &Pharmacology



Title : Amylin - Physiology and Pharmacology
Author : Andrew Young
Publisher: Academic Press
ISBN / ASIN: 0120329549
Deciphers amylin’s physiology and reveals previously unrecognized mechanisms fundamental to control body weight and fuel homeostasis. Also discusses therapeutic utility of amylin as the first new medicine to treat diabetes since insulin.
*Provides a current comprehensive treatment of amylin the hormone
*Identifies the majority of amylin’s physiologic functions
Download :

http://rapidshare.com/files/33839014/Amylin.pdf



Clinical Pharmacology Made Ridiculously Simple

Book Properties
ISBN: 094078050X
Title: Clinical Pharmacology Made Ridiculously Simple (MedMaster Series, Second Edition)
Author: James Olson
Publisher: Medmaster
Publication Date: 2003
Number Of Pages: 163
Average Amazon Rating: 3.5

http://mihd.net/5.6421/CLINICAL_PHAR...PLE.rar .html



Goldfrank’s Toxicologic Emergencies



By Neal E. Flomenbaum, Lewis R. Goldfrank, Robert S. Hoffman, Mary Ann Howland, Neal A. Lewin, Lewis S. Nelson,
Publisher: McGraw-Hill Professional
Number Of Pages: 1981
Publication Date: 2006-03-28
Sales Rank: 186988
ISBN / ASIN: 0071437630
EAN: 9780071437639
Binding: Hardcover
Book Description:
The #1 reference in the field for the last quarter of a century, Goldfrank's Toxicologic Emergencies, Eighth Edition, has been completely updated to equip emergency physicians with today's most authoritative guide to clinical toxicology. The book presents unsurpassed coverage of all aspects of toxicologic emergencies_from pharmacology and clinical presentation…to treatment guidelines and case studies. Using a unique case-study approach, Goldfrank's fully examines general principles and techniques…the biochemical and molecular basis of toxicology…and how toxins affect vital signs, organs, and systems throughout the body. The Eighth Edition now features:
A case-based approach that maximizes understanding of clinical applications of the material.
Antidotes in depth, offering easy-to-find, detailed guidance on the use of antidotes.
Quick-reference tables on inside covers, providing immediate access to “must-have” vital-sign statistics, lab values, and common equations.
New to the Eighth Edition: expanded coverage of bioterrorism, inhalant abuse, and international considerations
A companion website with more than 1200 self- assessment questions and annotated answers critical cases in medical toxicology reviewed in detail, 100 color photos of plants, mushrooms, spiders, snakes, marine life, and dermatologic reactions of toxicologic importance

http://rapidshare.com/files/27471953/TOXEMERG.rar

http://depositfiles.com/en/files/823395



Sedation Analgesia for Diagnostic and Therapeutic Procedures


S. Malviya, N. Naughton and K. K. Tremper (editors).
Published by Humana Press, New Jersey.
Pp. 310; indexed; illustrated. Price US$125.00. ISBN 0-89603-863-7.
Given the recent attempts by the Academy of Medicine to promote safer sedation, I had hoped that Sedation and Analgesia for Diagnostic and Therapeutic Procedures would contain helpful advice and guidance. I was greatly disappointed. With 18 of the 19 contributors coming from the USA, the book is clearly written for an American audience. All of the specific guidelines, rules and regulations are American, with no discussion of policies and practices in any other countries. While the basic principles may be similar, confusion is likely, as what is ‘mandatory’ in one place may only be ‘recommended’ elsewhere and vice versa. Predictably, American spellings are used, but alternative drug names used in Europe are not even acknowledged, which could be confusing and possibly dangerous.
Much of the book seems to lack focus. From the title, I would not expect sedation in the intensive care unit or general anaesthesia to be covered, except in passing. Unfortunately, several chapters devote many pages to these issues. That others do not implies a lack of editorial guidance and control. Material is often inappropriate for the target audience, claimed to range from investigators and physicians to nurses and administrators. For example, Chapter 5 Table 1 lists Malampatti class III as a risk factor that should trigger discussion with an anaesthetist. While I do not dispute this sage advice, the authors really should have defined the Malampatti classification, which I doubt would be known to anyone other than an anaesthetist. Practical tables and figures have not been used as consistently and effectively as the editors had hoped. The index also seems rather basic. Neither intranasal midazolam nor the aforementioned Malampatti classification are listed, despite several mentions in the text. The interaction of midazolam with opioids is indexed to only one of its multiple citations.
Chapter 1 is, in my opinion, the weakest, being confusing and unhelpful. It begins by highlighting differences between sedation and sleep, but then tries to explain both by way of common pathways. The authors use the bispectral index score (BIS) in support of their hypothesis, yet fail to mention that nitrous oxide can produce unconsciousness at normal BIS levels. Examples are often given for specific drugs, with no mention of how other members of the same class behave. A section on the pivotal role of GABA fails to mention propofol. There are also some errors, for example, nausea and vomiting are said to be ‘positively correlated with sedation level’, citing a study which actually showed nausea to be more common at light levels of sedation, probably because these less sedated patients also received more opioid analgesia.
Chapters 2 and 3 discuss American practice guidelines for paediatric and adult sedation, respectively. There is considerable overlap, but the second chapter is more useful, since it outlines various principles that would be helpful to anyone developing their own guidelines, and it contains valuable information on complication rates and monitoring. Chapter 4 provides specific advice for many paediatric procedures, but is a little disjointed. I would have liked a summary or table suggesting which types of procedure should involve an anaesthetist and which can be managed by other care providers, especially in the subsection on cardiology. Table 2 simply lists interventional radiology procedures; far more useful would have been to combine this with the subsequent text to suggest the likely level of sedation required for each procedure in tabular form. Table 3 could adopt a similar approach. Chapter 5, sedation by site and procedure, states that a comprehensive review of the use of various sedatives, analgesics and other adjuvants in bronchoscopy ‘is beyond the scope of this section’. I disagree and can see no better place for such a discussion, especially in a book aimed at a target audience which ‘spans multiple disciplines’.
Chapter 6 discusses the pharmacology of sedative agents, but three-quarters is devoted to general anaesthetic agents and often inappropriately deals with general anaesthesia or sedation in intensive care. Much of the basic pharmacology of these drugs will already be well-known to anaesthetists and, as much of the remainder of the book stresses, these drugs should not be used for sedation by other practitioners. Discussion of the various pharmaceutical preparations of propofol is again relevant only to the USA, while alternative formulations of etomidate (available in parts of Europe) receive no mention. The ‘dosage guidelines’ given in Table 5 would induce general anaesthesia in a great many cases, again suggesting a lack of focus. The following chapter discusses opioid pharmacology in considerable detail, but, bizarrely, this is confined to paediatric practice, in contrast to the more general handling of sedatives in the preceding text. Morphine is described as ‘the gold standard against which all other opioids are compared’, yet Table 1 normalizes all doses against meperidine (pethidine). The section on suggested morphine dose seems more relevant to postoperative or chronic pain, rather than to analgesia for diagnostic and therapeutic procedures. The description of oral transmucosal fentanyl refers only to its use for premedication. Chapter 8 briefly discusses monitoring standards (again, all American), before launching into a description of several monitoring devices. The detail is considerably more than I feel much of the readership will require. Unfortunately, some important ‘nuggets’, for example that pulse oximeters may be fooled into displaying saturations of around 80% by a popular American topical throat spray, are buried in the middle of some fairly advanced physics and may well be missed.
Chapter 9 reviews numerous methods for measuring sedation. While comprehensive, much again relates to sedation in the intensive care unit or general anaesthesia. What is particularly lacking is a simple summary suggesting which of the available measures are the most reliable during routine (sedation) practice. The following chapter provides a nursing perspective on the care of the sedated patient. Although there is much repetition from elsewhere, the ******** and style may make this section more accessible to those readers who are not anaesthetists. The short chapter on recovery and transport of sedated patients is good, although I would hope that better intraoperative management would reduce the number of patients who are still excessively sedated at the end of the procedure. The final chapter concerns quality assurance and continued improvement. Although the examples are again all American, there is a lot of information on the basic principles of quality management, including developing quality indicators and benchmarking. As a result, this chapter may be one of the most useful in the whole book.
This book does provide an interesting insight into American medical practice, where cost is often the driving factor. Some of the ‘turf wars’ between competing groups with vested interests will seem familiar. Despite the profusion of official guidelines in the USA, there is clearly a need for greater agreement and standardization, best illustrated by scary tales (p. 116) of cardiologists administering general anaesthesia for cardioversion, admittedly after ‘on-the-job training’.
In summary, this book may well be informative to those American readers for whom it was very clearly written. Elsewhere, it is likely to be confusing and frustrating, and I really cannot recommend its purchase by anyone other than librarians.

http://mihd.net/do8c5u

Pass:warez-bb

Advances in Vagal Afferent Neurobiology



Product Details
Book Publisher: CRC (01 June, 2005)
ISBN: 084932131X
Book author: Bradley J. Undem, Daniel Weinreich

Book Description:
Advances in Vagal Afferent Neurobiology takes a comprehensive approach in which all aspects of the vagal afferent system are considered from the terminals in the visceral tissues to the neural pathways within the central nervous system. Within this contextual framework, the book reviews the development, neurochemistry, anatomy, biophysics, pharmacology, and physiology of the vagal afferent nerves. The authors present experimental techniques used to investigate the development, morphology, electrophysiology, and reflex function of the vagal afferent nerves. The book includes state-of-the-art reviews of vagal afferent neurobiology by some of the world’s leading experts in these fields.

http://rapidshare.com/files/6620415/084932131X.rar



Drug ----bolism: Current Concepts



Product Details
Book Publisher: Springer (11 April, 2006)
ISBN: 1402041411
Book author: Mino R. Caira, Corina Ionescu

Drug ----bolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of ----bolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug ----bolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

http://mihd.net/f8wjy9



Peripheral Nerve Blocks: A Color Atlas, 2nd Edition



Thoroughly updated and greatly expanded for its Second Edition, this best-selling full-color atlas is a step-by-step guide to performing peripheral nerve blocks. For each nerve block, the book provides detailed information about indications, patient positioning, needle selection, drug selection and volume, anatomic landmarks, approach, and technique and offers tips for maximizing effectiveness and minimizing complications. Full-color clinical photographs and line art demonstrate anatomic landmarks, patient positioning, and techniques.
This edition features expanded coverage of the pharmacology of local anesthetics, a new section on pain blocks, and increased emphasis on continuous infusion blocks and pediatric peripheral nerve blocks. New chapters on upper and lower extremity innervation and facial blocks are also included.

Book details:
Author:Chelly , Jacques E
Publisher: Lippincott Williams & Wilkins; 2nd edition (September 1, 2003)
Pages:257
Size:56 MB
Format: compiled HTML help file

http://mihd.net/98f01l

password:DrWael

دى مجموعة فى Management of Pain
The 5-Minute Pain Management Consult (The 5-Minute Consult Series)

This new addition to The 5-Minute Consult Series is a clinically oriented quick-consult reference for pain management. More than 150 conditions associated with pain and concomitant mental health diagnoses are thoroughly and concisely presented in the famous fast-access 5-Minute Consult format. Each entry briefly describes the condition and presents succinct, bulleted facts under boldface headings: basics (epidemiology, risk factors, pathophysiology, etiology, prevention, associated conditions); diagnosis (signs and symptoms, history, physical exam, lab tests, imaging, differential diagnosis); treatment (medications, surgery); and follow-up (prognosis, issues for referral). Each entry includes ICD9-CM and CPT codes. Two Tables of *******s—one alphabetical and one organized by organ system—allow quick look-up of topics.
Book details:
Author:David M Sibell MD; Jeffrey R Kirsch MD
Publisher:Lippincott Williams & Wilkins; 1 edition (September 1, 2006)
Pages:344
Size:1,619 MB
Format:Compiled HTML help file (chm)
http://www.4shared.com/file/19457054...t_Edition.html
password: DrWael
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Bonica's Management of Pain

Bonica's Management of Pain is the "gold standard" text in pain management. This is the first and only textbook to take a comprehensive and practical approach to all areas of pain management, including its psychological issues. From cancer and surgical pain to visceral pain, this book covers diseases, treatments, causes, and effects. The first of three parts covers the fundamental aspects of pain, its anatomy, physiological and psychological bases. The second part addresses the techniques that alleviate pain and, though the primary focus is on analgesic block, other methods are covered. Clinical impressions and observations of diseases and disorders with painful syndromes constitute the third part of the book.
Book details:
Author:Chapman, Turk, Loeser, Butler
Publisher:Lippincott Williams & Wilkins; 3rd edition (January 15, 2001)
Pages:2178
Size:24,677 MB
Format:pdf
http://www.4shared.com/file/11493922...in_3rd_ed.html
password: DrWael
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Practical Management of Pain

PRACTICAL MANAGEMENT OF PAIN presents a comprehensive approach to chronic pain with its practical, concise descriptions of pain evaluation, pain syndromes, rationales for management, and treatment modalities. The book includes commonly seen pain syndromes, including headaches, trunk pain, orofacial pain, back pain, and extremity pain, as well as specific pain syndromes such as postoperative pain, pain due to cancer, phantom pain, and pain in the management of AIDS patients. This book is excellent both for non-specialists who treat the occasional pain patient and for physicians specializing in pain management.
Book details:
Author:P. Prithvi Raj
Publisher:Mosby; 3 edition (June 15, 2000)
Pages:1070
Size: 12,835 MB
Format: Compiled HTML help file (chm)
http://www.4shared.com/file/15610911...d_Edition.html
password: DrWael
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ودى مجموعة كتب واطلس فى regional anesthesia
Textbook of Regional Anesthesia

The Textbook of Regional Anesthesia certainly has a modern design where pain and regional anesthesia are integrated. Many topics concern new trends in regional anesthesia and the textbook deserves to be consulted particularly for that reason.
This authoritative and comprehensive reference by an international team of distinguished experts, explores all aspects of the field—from the basic science of regional anesthesia to its implementation in clinical practice. Up-to-date information is organized into a consistent, quick-access format that is highlighted by over 300 outstanding illustrations. No other book has as much information on setting up an Acute Pain Service, outcomes and evidence based medicine, as well as coverage on advanced interventional techniques.
Book details:
Author:P. Prithvi Raj, MD
Publisher:Churchill Livingstone; 1st edition (May 2002)
Pages:1083
Size:48,345 MB
Format:pdf
http://www.4shared.com/file/12736557...thesia__1.html
password: DrWael
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Handbook of Regional Anesthesia (ESRA, 2007)

This is the guide of European Society of Regional Anesthesia and Pain Therapy (ESRA) available on their official site, but not available as a printed book until now; so, this is not an official release, but a compendium of informations put assemble for those who need a portable guide for regional anesthesia.
The handbook is very sucint and yet very complete guide, and is having some really well done illustrations.
Book details:
Author:European Society of Regional Anaesthesia &Pain Therapy(ESRA)
Publisher:European Society of Regional Anaesthesia &Pain Therapy(ESRA)
Pages:130
Size:pdf(5,727 MB),pdb(18,162 MB )
Format:pdf&pdb
Pdf format:
http://www.4shared.com/file/12357129...arge_Pics.html
password: DrWael
Pdb format:
http://www.4shared.com/file/12357127...pics__PC_.html
password:DrWael
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Peripheral Nerve Blocks: A Color Atlas, 2nd Edition

Thoroughly updated and greatly expanded for its Second Edition, this best-selling full-color atlas is a step-by-step guide to performing peripheral nerve blocks. For each nerve block, the book provides detailed information about indications, patient positioning, needle selection, drug selection and volume, anatomic landmarks, approach, and technique and offers tips for maximizing effectiveness and minimizing complications. Full-color clinical photographs and line art demonstrate anatomic landmarks, patient positioning, and techniques.
This edition features expanded coverage of the pharmacology of local anesthetics, a new section on pain blocks, and increased emphasis on continuous infusion blocks and pediatric peripheral nerve blocks. New chapters on upper and lower extremity innervation and facial blocks are also included.
Good atlas of regional anaesthesia
Book details:
Author:Chelly , Jacques E
Publisher: Lippincott Williams & Wilkins; 2nd edition (September 1, 2003)
Pages:257
Size:56 MB
Format: compiled HTML help file
http://mihd.net/98f01l
password:DrWael
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Postoperative Pain Management-
Good Clinical Practice

General recommendations and principles for successful pain management.Prepared by a group of experts in cooperation with European Society of Regional Anaesthesia and Pain Therapy.
Effective postoperative pain management has a humanitarian role, but there are additional medical and economic benefits for rapid recovery and discharge from hospital. A number of factors contribute to effective postoperative pain management including a structured acute pain management team, patient education, regular staff training, use of balanced analgesia, regular pain assessment using specific assessment tools and adjustment of strategies to meet the needs of special patient groups, such as children and the elderly. Recent advances in pain control provide greater potential for effective postoperative management.
This document reflects the opinions of a panel of European anaesthesiologists. Its aims are to raise awareness of recent advances in pain control and to provide advice on how to achieve effective postoperative analgesia. The recommendations and advice are general principles of pain management and do not provide detailed advice for specific surgical procedures.
Booklet details:
Author:Dr Jose De Andrés, MD, PhD
Publisher:Astra Zenca
Size:7,2 MB
Format:PDF
http://mihd.net/d78hlv
او
http://www.esraeurope.org/postoperat...Management.pdf

Anaesthesia at the District Hospital (2nd Edition)

A practical manual designed to help medical officers in small hospitals acquire competence in the use of essential techniques for inducing anaesthesia.
Procedures for both elective surgery and emergency care of the critically ill are considered. This second edition has been substantially revised to reflect changes in clinical practice, equipment and drugs, since the publication of the first edition.
The manual opens with a description of the fundamental principles and techniques underlying the practice of anaesthesia.
Guidelines cover the immediate and continuing care of the critically ill, unconscious, or anaesthetized patient and the principles of fluid and electrolyte therapy.
Against this background, chapters explain the methods, equipment and drugs used to induce general and regional anaesthesia.
Particular attention is given to the use of draw-over anaesthesia as the technique of first choice for general anaesthesia in small hospitals.Other chapters discuss the special needs of paediatric and obstetric anaesthesia and outline a number of medical conditions important for the anaesthetist.
Book details:
Author: M.B. Dobson
Publisher: World Health OrganizationPublication
Pages: 153
Size:8,30
Format:PDF
http://whqlibdoc.who.int/publications/9241545275.pdf
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Hypertextbook of Regional Anaesthesia for Obstetrics

An outline format of a published work that covers all aspects of anatomy, neonatology, pharmacology, resuscitation, cesarean section, general & spinal anaesthesia, etc.
Offers a subject and drug index.
Editors: Stephen P Gatt and Andrew Pybus.
Sub-editors: Leonie Watterson and Clive Collier
http://manbit.com/oa/oaindex.htm
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Guidlines for Pediatric Regional Anaesthesia

his is short notes by Elliot Krane M D in regional anaesthesia in childern departement of anaesthesia ana pain management,Lucile Pakard Childern Hospital stanford univeristy medical center
http://pedsanesthesia.stanford.edu/
http://pedsanesthesia.stanford.edu/
First section will discuss differences between childern and adult as far as the performance of regional anaesthesia is concerned. the majority of the discussion will be reserved for the examination of the controversies surrounding the performance of regional anaesthesia in anaesthesized subjects who are unable to report the existence of paraesthesia,whether this might increase the risk of regional anaesthesia
The last section about how to do peripheral blocks in childern
Booklet details:
Author:Elliot Krane
Publisher:departement of anaesthesia ana pain management,Lucile Pakard Childern Hospital stanford univeristy medical center
Pages: 28
Size: 548 KB
Format:pdf
http://mihd.net/qi6edy
password: DrWael
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Tutorial in Peripheral Regional Anaesthesia

This is third expanded edition of Tutorial in Peripheral Regional Anaesthesia
Despite increasing use in recent years, peripheral regional anaesthesia techniques continue to occupy a rather secondary position in comparison to spinal procedures. This is particularly the case for peripheral blockade techniques of the lower extremities.
Book details:
Author: profH.-H.Meherkens,M.D,P.M.Geiger,M.D .
Publisher: Departement of anaesthesiology/intensive care medicineUlm Rehabilitation hospital
Pages: 64
Size: 0,9 MB
Format: PDF
http://mihd.net/0ict7y
password: DrWael

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